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What Is PRGF?

PRGF also known as Plasma Rich in Growth Factors is an FDA approved medical treatment that we offer that uses a patient's own blood to help heal injuries or tissue damage. The patient's blood is processed to concentrate the platelets and growth factors, which are then injected back into the body.

How Is PRGF Different from PRP?

While both PRGF and PRP involve the use of the patient's own blood to promote healing, they differ in the way the blood is processed.

PRP involves processing the blood to concentrate the platelets and growth factors, which are then injected back into the patient's body to promote healing. PRGF is a similar process but with a different technology used to concentrate the growth factors specifically.

The ENDORET® KIT, for instance, is designed to rapidly prepare PRP from a small sample of peripheral blood.

While both therapies use the patient's blood to promote healing, PRGF is used for more severe medical issues in the body.

Benefits of PRGF

  • Stimulates tissue repair process with hundreds of endogenous proteins
  • Promotes new blood vessel formation, cell mobilization, and proliferation
  • Contains fibrin for balanced and gradual release of growth factors
  • Accelerates healing and minimizes inflammation
  • Reduces pain and speeds up recovery time


What is Intraosseous PRGF for the knees and how does it work?

Our intraosseous PRGF treatment for the knees is a medical service that involves the injection of Platelet-Rich Plasma directly into the bone marrow of the knee. The procedure is done under sterile conditions and is intended to help with knee pain and other symptoms. Intraosseous PRGF works by providing the knee joint with a concentrated source of growth factors that are believed to have a positive effect on knee health.

How can PRGF help treat musculoskeletal and spinal issues?

PRGF can potentially help treat musculoskeletal and spinal issues within some patients. When PRGF is injected into an affected area, the concentrated growth factors in the plasma can stimulate the body's natural healing processes and help to repair damaged tissues. This can lead to reduced pain and improved mobility in patients with musculoskeletal or spinal issues.

How many injections should be given for Knee OA treatment?

Most studies suggest that having more than one injection can lead to better results, especially for early OA. However, the number of injections may depend on factors like the PRP product used, including injection volume and platelet concentration. Based on a consensus group, the recommended range is 2-4 injections, with a grade B recommendation.

Which is better for treating Knee OA: PRP or hyaluronic acid injections?

Studies and meta-analyses have compared PRP and HA for knee OA treatment, with most showing better clinical improvement and longer-lasting effects with PRP. Based on current evidence, PRP is preferred over HA, but differences in product formulations may affect results.

Learn More About PRGF with Dr. Heidi Seifert

If you are ready to learn more about PRGF and how it may benefit you, please give us a call or fill out a contact form with your information and questions you may have and we will get in touch with you shortly.

Seifert M.D.

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